Detailed Mechanism Funding and Narrative

Years of mechanism: 2008 2009

Details for Mechanism ID: 3106
Country/Region: Vietnam
Year: 2009
Main Partner: National Institute for Hygiene and Epidemiology - Vietnam
Main Partner Program: NA
Organizational Type: Host Country Government Agency
Funding Agency: HHS/CDC
Total Funding: $280,000

Funding for Laboratory Infrastructure (HLAB): $20,000

This is a continuing activity from FY08.

In keeping with Vietnam's National HIV/AIDS Strategy and PEPFAR's 5-year Strategy, FY09 funds and will

be provided to the National Institute of Hygiene and Epidemiology (NIHE) for numerous laboratory activities.

These include HIV rapid test field evaluation (phase II); dissemination of a national HIV diagnostic algorithm

(using rapid tests); coordination of the national external quality assurance (EQA) program for HIV serology,

estimation of a local HIV-incidence (BED assay) misclassification rate, patient monitoring for HIV drug

resistance in outpatient clinics in high prevalence provinces and expansion of HIV early infant diagnosis to

all provinces offering prevention of mother-to-child transmission (PMTCT) services. NIHE and the Pasteur

Institute are developing similar, reference laboratory-like roles related to HIV; each covers different ends of

the country. NIHE is a resource for Vietnam's Ministry of Health (MOH) in setting policy and developing

national testing guidelines.

The evaluation by NIHE and the Pasteur Institute of Ho Chi Minh City of HIV rapid tests is one part of a plan

to help MOH develop a single HIV diagnostic algorithm based on simple, rapid testing technologies.

PEPFAR funding from previous years has been provided for this activity, but only recently has there been

such a high level of interest and urgency within the MOH's Vietnam Administration for HIV/AIDS Control for

the completion of this activity. In mid-2008 Vietnam, hosted a World Health Organization (WHO)-sponsored

regional HIV testing meeting (with CDC support). The protocol for the initial laboratory based evaluation

(phase I) has been completed (using the internationally accepted WHO/CDC guidelines) and approved by

both the government of Vietnam and CDC (Internal Review Board). Sample collection, characterization,

testing, and data analysis will occur in early 2009. Based on the results of this initial evaluation, tests will be

selected for field evaluation (phases II) at selected testing sites in late 2009. NIHE and PI will provide

training and supervision to testing sites and will characterize study specimens. Resulting data will be used

by the Ministry of Health (and stakeholders) to make recommendations for testing algorithms that will be

implemented with education and training programs. An HIV diagnostic quality assurance program will be

developed around the new algorithm (phase III) and will be based at NIHE to support the northern provinces

(the Pasteur Institute will support the southern provinces). This will include a combination of training,

internal QA, external QA, retesting, and site monitoring.

PEPFAR continues to support the development of NIHE's HIV molecular testing laboratory, which is

responsible for HIV drug resistance monitoring for antiretroviral therapy clients and threshold surveys. To

date, support has included staff training, limited infrastructure improvements, and reagent procurement. For

FY09 PEPFAR will provide long-term (three month) technical assistance (TA) through its laboratory coalition

partner, the Association of Public Health Labs (APHL). A former molecular laboratory director will serve as a

mentor to the current director (see APHL activity narrative for additional detail).

Development of an efficient early infant diagnosis (EID) program for HIV-exposed infants, linked to PMTCT

services, continues to be a goal of Vietnam's Ministry of Health. NIHE, with PEPFAR support, is seeking

approval from the government of Vietnam for use of Roche Amplicor DNA PCR 1.5 kits. A protocol has

been developed and approved for EID implementation; NIHE and the Pasteur Institute are jointly designated

as technical leads. Dried blood spots (DBS) will be used for specimen collection. PEPFAR will collaborate

with the Clinton HIV/AIDS Initiative, which is providing sample collection materials and test kits. TA will be

provided by PEPFAR for collection and testing site training and development of a comprehensive quality

assurance (QA) program for EID. In FY09, EID services will be expanded to more provinces.

In the past, PEPFAR supported NIHE in the implementation of various laboratory QA-strengthening

activities. Laboratory technicians from 55 provinces have been provided vendor-supported EIA training on

equipment use and preventive maintenance. Service contracts were put in place for biological safety hoods

and pipettes. Two new laboratory technicians were hired to conduct site visits and data analyses. NIHE will

develop standard operating procedures for laboratories at the national, regional, and provincial levels for

quality assurance and laboratory safety. In FY09, PEPFAR will provide support to NIHE for the continuation

of these activities.

NIHE currently supports a national HIV EQA program. In FY08, PEPFAR assisted in the procurement of

equipment necessary for the production of the serology panels. In collaboration with the Thai Ministry of

Public Health (TMOPH) and PEPFAR, NIHE has validated and calibrated this equipment and characterized

EQA panels. The Hanoi School of Public Health (HSPH) is working with NIHE to adapt the EQA software

provided by Thailand to Vietnam. Staff at NIHE received additional training from TMOPH and WHO

regarding production of EQA panels and data analyses to generate reports. Three proficiency rounds have

been completed. PEPFAR will continue to fund the expansion of this EQA program as a component of the

national quality management system.

New/Continuing Activity: Continuing Activity

Continuing Activity: 15301

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

15301 5709.08 HHS/Centers for National Institute 7115 3106.08 $315,500

Disease Control & for Hygiene and

Prevention Epidemiology

9506 5709.07 HHS/Centers for National Institute 5102 3106.07 NIHE $319,474

Disease Control & for Hygiene and Cooperative

Prevention Epidemiology agreement

5709 5709.06 HHS/Centers for National Institute 3106 3106.06 Cooperative $220,000

Disease Control & for Hygiene and agreement

Prevention Epidemiology

Table 3.3.16:

Funding for Strategic Information (HVSI): $260,000

This is a continuing activity from FY08.

HCD - Training and TA: $40,000

Data Triangulation: $40,000

GIS: $20,000

HMIS: $20,000

Incidence Surveillance: $70,000

Sentinel Surveillance: $70,000

As the leading disease surveillance institute in Vietnam, the National Institute of Hygiene and Epidemiology

(NIHE) will continue gathering and analyzing epidemiological data to inform policy and programs and

contribute to human capacity development in epidemiology. NIHE is currently collaborating with the

HHS/CDC Global AIDS Program (GAP) Surveillance and Laboratory Branches to obtain the correction

factor for the BED HIV-1 incidence assay for Vietnam. With COP FY 2009 funds, NIHE will apply BED to

stored and new specimen from sentinel surveillance and integrated biological and behavioral surveillance

(IBBS) to track incidence among most at risk populations. Incidence data are key data currently unavailable

for prevention program planning in Vietnam; this activity will provide baseline data for future PEPFAR and

national strategy planning. Funds will be used for laboratory supplies and transportation; PEPFAR will

procure BED kits.

To address low field surveillance capacity, NIHE will continue to strengthen the capacities of regional

epidemiology institutes and provincial implementing partners in ensuring quality sentinel surveillance data.

Funds will be used for regional refresher trainings, quality assurance systems establishment, field QA

activities, and dissemination workshop.

By 2009, in addition to incidence surveillance, the second round of IBBS, MARP size estimation, and

behavioral survey among male client of sex workers will have been completed. Along with the Vietnam

Administration for HIV/AIDS control, NIHE will co-chair a technical working group to triangulate these data

with program data and disseminate findings to stakeholders.

NIHE will also collaborate with local public health and medical universities to develop epidemiology

concentrations at these universities and scholarship programs to encourage greater enrollment in

epidemiology programs. NIHE will also engage in curriculum development and lectures of short-course in-

service epidemiology training, which will be coordinated by and funded through the Hanoi School of Public

Health.

NIHE will also participate on the GIS technical working group, supporting training and data collection and

contributing epidemiological data to the project.

Furthermore, NIHE will improve information systems around surveillance, size estimation, and other

epidemiological data for data management and sharing among GVN and other stakeholders.

New/Continuing Activity: Continuing Activity

Continuing Activity: 15302

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

15302 5694.08 HHS/Centers for National Institute 7115 3106.08 $610,000

Disease Control & for Hygiene and

Prevention Epidemiology

9244 5694.07 HHS/Centers for National Institute 5102 3106.07 NIHE $165,314

Disease Control & for Hygiene and Cooperative

Prevention Epidemiology agreement

5694 5694.06 HHS/Centers for National Institute 3106 3106.06 Cooperative $225,000

Disease Control & for Hygiene and agreement

Prevention Epidemiology

Emphasis Areas

Military Populations

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $40,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.17:

Cross Cutting Budget Categories and Known Amounts Total: $40,000
Human Resources for Health $40,000