Detailed Mechanism Funding and Narrative

Years of mechanism: 2008 2009

Details for Mechanism ID: 1404
Country/Region: Namibia
Year: 2009
Main Partner: Namibia Institute of Pathology
Main Partner Program: NA
Organizational Type: Parastatal
Funding Agency: HHS/CDC
Total Funding: $2,144,093

Funding for Treatment: Adult Treatment (HTXS): $35,000

NEW/REPLACEMENT NARRATIVE

This continuing activity supports the National ART Program by providing a dedicated technologist to perform

viral load tests.

The Namibia Institute of Pathology (NIP) is responsible for provision of all HIV-related testing technologies

for the public sector at the national level. During February 2006, the national ART treatment guidelines

were updated to include viral load testing for patients suspected to be failing treatment. With the growing

number of patients on ARVs in Namibia, viral load testing has become an increasingly critical part of bio-

clinical monitoring. Guidelines have included more routine measurement of HIV-1 viral load at 6 months on

ART patients and screening for treatment failure. With the help of USG, NIP has equipped a state-of-the-art

molecular biology lab with viral load testing capacity. Anticipating increasing demand for viral load testing,

the dedicated lab technician hired and placed at NIP to perform this service will continue to be supported. It

is expected that over 12,000 viral load tests will be performed in FY09 and this technologist is needed for

NIP to have sufficient capacity to meet demand. This person will continue to receive technical assistance

from the CDC laboratory scientist assigned to NIP.

New/Continuing Activity: Continuing Activity

Continuing Activity: 16166

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

16166 7975.08 HHS/Centers for Namibia Institute 7367 1404.08 Cooperative $35,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

7975 7975.07 HHS/Centers for Namibia Institute 4384 1404.07 Cooperative $40,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

Emphasis Areas

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $35,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.09:

Funding for Care: Pediatric Care and Support (PDCS): $35,000

NEW/REPLACEMENT NARRATIVE

This is a continuing activity and provides funding for the salary of a dedicated technologist in support of

early infant HIV diagnosis by PCR.

The Namibia Institute of Pathology (NIP) is responsible for provision of all HIV-related testing technologies

for the public sector. During COP FY 2005, the diagnostic algorithm for using dried blood spots (DBS) and

PCR for pediatric diagnosis was developed and field-tested in Namibia. During COP FY 2006, the Ministry

of Health and Social Services (MOHSS) PMTCT program and NIP introduced this method for testing

symptomatic infants and screening HIV-exposed infants at six weeks of age. Laboratory staff have been

trained in PCR, new equipment has been procured, specimens are being processed, and the rollout of

decentralized training of health workers in the collection of DBS is ongoing. It is expected that 20,000

diagnostic PCR tests will be performed in COP FY 2009 and a dedicated technologist is needed for the

laboratory to have sufficient capacity in response to increasing demand. This person is being supported with

technical assistance from the CDC laboratory scientist assigned to NIP.

New/Continuing Activity: Continuing Activity

Continuing Activity: 16163

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

16163 7927.08 HHS/Centers for Namibia Institute 7367 1404.08 Cooperative $40,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

7927 7927.07 HHS/Centers for Namibia Institute 4384 1404.07 Cooperative $40,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

Emphasis Areas

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $35,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.10:

Funding for Care: TB/HIV (HVTB): $265,000

NEW/REPLACEMENT NARRATIVE

Namibia has one of the highest rates of tuberculosis in the world and TB currently is the leading cause of

death for persons living with HIV. In addition to multi-drug resistant (MDR) TB, Namibia is facing the added

challenge of identifying and responding to the emergence of extensively drug resistant (XDR) TB. There is

also a continuous need to improve the laboratory surveillance of MDR/XDR TB cases and reporting to the

National TB Control Programme (NTCP).

This is a continuing activity from FY 2008 COP and has five components: (1) strengthening the Namibia

Institute of Pathology (NIP) tuberculosis laboratories by procurement of equipment; (2) expanding TB

diagnostic techniques; (3) improving quality assurance (QA) by hiring a QA staff person; (4) strengthening

bio-safety; and (5) supporting TB laboratory staff. (USG support for TA and other costs for TB drug

resistance surveillance in COP 09 is described in the MOHSS Strategic Information narrative. NIP cost

analysis is to be undertaken with COP 08 resources by APHL and MOHSS.)

1. Continue to strengthen the Namibia Institute of Pathology (NIP) tuberculosis laboratories. This

component will continue to improve NIP's capacity to process a greater volume of testing. In FY 2007 COP,

five MGIT 960 instruments were purchased and installed in the laboratory to replace the BACTEC 460

radiometric system, and the lower-capacity BactAlert instruments. Also in FY 2007 COP, two consultants

from the American Society of Microbiology spent three months in the TB Lab assisting with culture/DST and

quality assurance. This support resulted in more accurate testing of patient specimens. However, there is

a continued need to decentralize the TB culture and sensitivity testing to some high-burden areas served by

peripheral laboratories. Two high burden sites have been identified and two more MGIT 960 instruments

will be purchased to establish testing in these laboratories.

2. Expand TB diagnostic techniques. Rapid identification of MDR/XDR TB cases is important for better

patients' management. This component will continue to roll out fluorescence microscopy at TB laboratories

and expand the use of rapid TB diagnosis techniques at NIP, specifically Hain line probe assay. In FY 2008

COP, fluorescence microscopy was introduced at some of the high burden sites and rapid TB diagnosis

techniques were evaluated. In FY 2009 COP, at least 10 fluorescent microscopes will be procured.

3. Improve the Quality Assurance (QA) component of TB diagnosis. The QA for TB diagnostic testing has

been found to be a weakness by previous consultancies and assessments. In FY 2007 COP and FY 2008

COP, funding was allocated to hire a TB QA person dedicated to basic smear microscopy. With the

expansion of C/DST it is expected that the QA person will take a lead role in overall QA related to TB Lab

testing.

4. Strengthen bio-safety, TB specimen transport, and waste management. One of the primary concerns

during the TB laboratory assessments was bio-safety. In FY 2007 and FY 2008 COP bio-safety cabinets

were purchased for all NIP laboratories performing TB diagnosis. In FY 2009 COP, additional renovations

and improvements in labs will be conducted to improve safety. With MDR/XDR TB cases detected in

Namibia by NIP labs, it is important to have measures in place to protect the health workers as well as

avoiding risky handling of TB suspects' specimens. With its own resources, NIP has implemented a health

and safety policy that covers screening for TB for staff with potential occupational exposure.

5. Support salaries of two medical technologists, one for QA (see activity 3) and one as the TB Central Lab

Supervisor. Salaries for six laboratory assistants will also be supported. These staff members are part of

NIP's staff establishment, and as such, they are supervised as part of the NIP structure. The CDC

laboratory technical advisor who is placed at NIP mentors these and other NIP staff on a day-to-day basis.

New/Continuing Activity: Continuing Activity

Continuing Activity: 16164

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

16164 7971.08 HHS/Centers for Namibia Institute 7367 1404.08 Cooperative $265,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

7971 7971.07 HHS/Centers for Namibia Institute 4384 1404.07 Cooperative $848,500

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

Emphasis Areas

Health-related Wraparound Programs

* TB

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $160,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.12:

Funding for Testing: HIV Testing and Counseling (HVCT): $870,000

NEW/REPLACEMENT NARRATIVE

This is a continuing activity that contains two components which serve as the foundation for the quality

assurance (QA) provided at the national level to all rapid HIV testing sites in Namibia. In FY09, funding is

being requested for: (1) ongoing rapid testing (RT) QA support (evaluation of new RT kits, preparation of

starter packs, provision of quality controls and proficiency panels, oversight of certification processes,

ELISA tests for 5% retesting of all rapid tests performed, and supervision of RT sites); (2) salary support for

7 staff (1 national communicable disease (CD) QA manager, 1 national HIV RT QA manager, 3 QA medical

technologists, and 2 administrative assistants).

These activities support rapid and extensive expansion of provider-initiated testing and counseling (PITC)

as well as existing VCT. The NIP is responsible for validation of any new RT technologies before being

used in Namibia and for making recommendations to the Ministry of Health and Social Services (MOHSS)

on the RT algorithm and selection of test kits; training and post-training certification of all rapid testers

before they can issue results to clients; site inspection of all new RT sites to ensure that they meet the

minimum standards; preparation, distribution, and follow-up analysis of quality controls and proficiency

panels that are sent to RT sites; retesting of 5% of all rapid tests done at sites by ELISA and addressing any

performance issues with the tester; and submission of reports on rapid test QA to the MOHSS CT unit.

To date a total of 1,043 testers including health workers and community counselors have been successfully

trained. Among these, 887 have been certified and 156 are in the process of certification. From July 2008

to September 2008, 3,234 retests were performed for testers' certification and 1,566 retests performed as

part of the current quality assurance standard which requires 10% retesting. NIP and the MOHSS have

since agreed to lower the retesting standard to 5%. During the same period, 148 sets of External Quality

Assurance proficiency panels and 370 Quality Control sets were sent out to the RT sites.

New/Continuing Activity: Continuing Activity

Continuing Activity: 16165

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

16165 7992.08 HHS/Centers for Namibia Institute 7367 1404.08 Cooperative $920,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

7992 7992.07 HHS/Centers for Namibia Institute 4384 1404.07 Cooperative $691,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

Emphasis Areas

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $165,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.14:

Funding for Laboratory Infrastructure (HLAB): $939,093

NEW/REPLACEMENT NARRATIVE

This activity contains four components: (1) procurement and maintenance of equipment; (2) renovation of

laboratories; (3) laboratory training; and (4) salary support for laboratory trainers and an administrative

assistant.

1. Namibia's antiretroviral treatment program is rapidly expanding with emphasis on bringing these services

closer to patients in remote areas. By its mandate, the Namibia Institute of Pathology (NIP) is required to

support the treatment program wherever it is launched. NIP will continue to strengthen its peripheral

laboratories in providing diagnostics and basic bio-clinical monitoring services accessible to the patients in

remote areas. This will minimize transport of samples to central testing facilities and improve turnaround

time. Funds will be used to procure and maintain laboratory equipment for this purpose.

2. Renovations of the molecular diagnostic laboratory and selected peripheral NIP laboratories will

accommodate the high volume of testing, make work places safer for laboratory workers, and improve

turnaround times.

3. Support the NIP laboratory training unit to handle logistics of all trainings. During FY07 and FY08,

ITECH was funded to provide logistical support to the training unit. This responsibility will be handled by

NIP's training unit in FY09, a more sustainable arrangement. Workshops will be organized with assistance

of the International Laboratory Branch (ILB) consortium partners. The presenting partner will be selected

depending on NIP's ongoing training needs. Potential areas for training will be: laboratory management,

including strategic planning for the national laboratory system (APHL); bio-monitoring assays such as CD4

methods and instrumentation, chemistry and hematology (ASCP); OI focusing on tuberculosis smear

microscopy, culture and drug susceptibility testing, and bio-safety (ASM); and standardized laboratory

methodology and quality assurance (CLSI). Funds will be allocated to send NIP staff to attend

complementary trainings at the African Center for Integrated Laboratory Training (ACILT) in Johannesburg

as well as relevant trainings outside of Namibia.

4. Support the salaries of the 2 technical trainers and the administrative assistant assigned to the training

unit.

New/Continuing Activity: Continuing Activity

Continuing Activity: 17320

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

17320 17320.08 HHS/Centers for Namibia Institute 7367 1404.08 Cooperative $826,000

Disease Control & of Pathology Agreement

Prevention U62/CCU02441

9

Emphasis Areas

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $380,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.16:

Cross Cutting Budget Categories and Known Amounts Total: $775,000
Human Resources for Health $35,000
Human Resources for Health $35,000
Human Resources for Health $160,000
Human Resources for Health $165,000
Human Resources for Health $380,000