Detailed Mechanism Funding and Narrative

Years of mechanism: 2008 2009

Details for Mechanism ID: 8141
Country/Region: Ethiopia
Year: 2009
Main Partner: University of Connecticut
Main Partner Program: NA
Organizational Type: University
Funding Agency: USDOD
Total Funding: $200,000

Funding for Treatment: Adult Treatment (HTXS): $200,000

Adherence Support for HIV Positives

The current proposal aims to develop, implement, and evaluate an ARV adherence-support program for HIV

-infected military members and spouses who attend military clinics in Ethiopia. The university of

Connecticut's Center for Health, Intervention, and Prevention (CHIP) will work collaboratively with

representatives from the National Defense Forces of Ethiopia (NDFE), the University of California, San

Diego (UCSD), and the US Department of Defense HIV/AIDS Prevention Program (DHAPP) to develop an

ARV adherence-support program that is acceptable to staff and patients. This program is feasible to

implement in the clinical care setting, can be delivered with fidelity, and is effective at increasing the ARV

adherence of HIV - positive soldiers and spouses. This theory-based, ARV adherence-support program will

be adapted and tailored to the socioeconomic, cultural, and healthcare context of Ethiopia and the Ethiopian

military, and will be implemented in multiple military healthcare sites.

There is no doubt that maintaining optimal ARV adherence is challenging for people living with HIV/AIDS

(PLWH), but it is likely even more challenging for PLWH in the NDFE. They face ARV adherence barriers

that are unique to military life, such as combat and other deployment situations that make it particularly

difficult to access, store, and take medications as prescribed. In addition, because soldiers live and work in

such close quarters, they may be more likely to skip doses of their medications because of fears that they

will be observed taking their medications and thus reveal their HIV status and be exposed to HIV - related

stigma. These additional barriers increase the probability that members of the NDFE will be unable to

achieve and maintain optimal levels of ARV adherence necessary for reaping the health benefits of

treatment. Military PLWH who are unable to maintain high rates of adherence over time may not only

exhaust their options for treatment through the development of ARV resistance, but may also pose a larger

public health threat if they fail to consistently practice safer sex behaviors and transmit their drug-resistant

strain of HIV to others. With over 3,500 troops and family members in Ethiopia receiving ARV treatment

(DHAPP Country Report, 2006), it is therefore critical that programs be developed that provide PLWH in the

NDFE with the tools that they need to properly adhere to their ARV medications.

GOALS and OBJECTIVES

(1) Conduct a needs assessment to identify the dynamics of non-adherent behavior among HIV-positive

soldiers and spouses, and to determine what is feasible and practical to do in military healthcare settings.

We will conduct a minimum of five focus groups (two female PLWH, two male PLWH, and one staff focus

group) at each military hospital site in Ethiopia that participates in this project. The specific goals of the

needs assessment work are to: (a) explore the dynamics of non-adherence among Ethiopian military

PLWH; (b) identify culturally appropriate strategies that Ethiopian military PLWH can use to increase their

adherence to ART; (c) determine whether the adherence-support program should be delivered in a group or

one-on-one format; (d) determine which individuals (e.g., doctors, nurses, counselors, pharmacists, and/or

peer educators) are most appropriate for implementing the adherence-support program and what their

specific training needs are; and (e) assess how to most effectively and efficiently integrate the adherence-

support program into the daily clinic routine. There will be 6-10 participants in each focus group.

(2) Based on the findings from the needs assessment, develop a tailored ARV adherence-support program

that addresses the specific adherence needs of HIV-positive military and spouses in Ethiopia. Once the

focus groups are completed, the findings will be compiled and analyzed, and an adherence-support

program developed. Our Ethiopian Collaborators (representatives of the NDFE and DHAPP) will play a

central role in the framing, conduct, and analysis of the needs assessment and its integration into the final

adherence-support program. The needs assessment and multidisciplinary collaboration will allow us to

tailor the adherence-support program. The needs assessment and multidisciplinary collaboration will allow

us to tailor the adherence-support program to the clinic site and the particular needs of its integration into

the final adherence-support program. The needs assessment and multidisciplinary collaboration will allow

us to tailor the adherence-support program. The needs assessment and multidisciplinary collaboration will

allow us to tailor the adherence-support program to the clinic site and the particular needs of its HIV-positive

patients.

(3) Train Ethiopian military interveners in the ARV adherence-support program. The content of the

adherence-support program and the training protocol will be based upon: (1) the findings from the needs

assessment; (2) the US team's extensive experience developing adherence-support programs in Uganda

and the US and training interveners to deliver them; and (3) extensive input and feedback from the

multidisciplinary Ethiopian team. Interveners (e.g., doctors, nurses, psychologists, counselors, pharmacists,

and/or peer educators) will be jointly trained by the US team and at least one medical provider (preferably

someone from the NDFE) with expertise in ARV medications and adherence issues. One of the interveners

will eventually be selected and trained as a master trainer in the program protocol. This individual will

continue to provide training once the US-led portion of the project is completed.

(4) Implement the ARV adherence-support program at multiple military healthcare sites within Ethiopia. At

all sites, trained interveners will implement the adherence-support program on an ongoing basis when

patients come in for their routine clinical care visits. Depending on the format of the adherence-support

program (which will be determined as a function of the needs assessment and in collaboration with the

Ethiopian-DHAPP team), patients will either participate in group adherence-support sessions or in one-on-

one discussions with an intervener. If the adherence-support program is offered in a group format, different

adherence-related topics will be presented each month (e.g., how ARV medications work in the body,

strategies for remembering to take one's medications, managing side effects, learning from a missed dose,

effective communication with one's healthcare provider, disclosing one's HIV status, dealing with HIV-

related stigma, and managing one's stress levels). Each group session will include an interactive

component to encourage active participation in the group.

If instead, the format of the program is one-on-one, patients will meet individually with an intervener at each

routine clinical care visit. Each session will consist of a patient-centered discussion in which the intervener

works collaboratively with the patient to identify and understand the dynamics of the patient's ARV non-

adherence and to develop strategies to help him/her consistently adhere to his/her ARV medication

regimen. Specifically, these discussions will: identify patients' informational, motivational, and behavioral

skills barriers to taking their ARV medications as prescribed; provide critical ARV adherence information,

Activity Narrative: motivation, and behavioral skills to overcome the barriers; and set specific adherence-related goals for

PLWH to accomplish between clinical care visits as a means of enhancing their adherence. Subsequent

discussions between HIV-positive patients and their interveners will focus on: monitoring progress toward

their goals; providing additional information, motivation, and behavioral skills training as needed; and

negotiating a new goal, when appropriate.

(5) Evaluate the effectiveness of the adherence-support program by comparing the pre-program ARV

adherence to the post-program adherence of 150 to 200 PLWH. An in-country project assistant will recruit

a randomly selected sample of 75-100 HIV-positive NDFE military personnel on ARVs, and 75-100 HIV-

positive military members' spouses on ARVs to complete the program-evaluation measures. The project

assistant will administer measures of ARV adherence to these patient participants prior to the first

adherence support session (at baseline) and then again at four-month and eight-month intervals following

the patients' first adherence support sessions. The project assistant will also review each enrolled patient's

medical chart to obtain any available CD4 and pill count data. Baseline levels of self-reported adherence

behavior, pill counts, and CD4 counts will be compared to follow-up levels taken at four and eight months,

respectively. This will allow us to evaluate the effectiveness of the program at improving ARV adherence

behavior using three different indicators. We will also evaluate whether the adherence-support program is

differentially effective with soldiers and soldiers' spouses.

New/Continuing Activity: Continuing Activity

Continuing Activity: 18704

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

18704 18704.08 Department of University of 8141 8141.08 DOD-UCONN- $225,000

Defense Connecticut PWP

Emphasis Areas

Military Populations

Human Capacity Development

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.09: