Detailed Mechanism Funding and Narrative

Years of mechanism: 2008 2009

Details for Mechanism ID: 3010
Country/Region: Zambia
Year: 2008
Main Partner: Chest Diseases Laboratory
Main Partner Program: NA
Organizational Type: Host Country Government Agency
Funding Agency: HHS/CDC
Total Funding: $100,000

Funding for Laboratory Infrastructure (HLAB): $100,000

The funding level for this activity in FY 2008 has decreased since FY 2007. Only minor narrative updates

have been made to highlight progress and achievements.

This activity is linked to all TB/HIV activities nationally and to ASM, CDC Lab TA, TDRC and SCMS.

The Chest Diseases Laboratory (CDL) is Zambia's National Tuberculosis (TB) Reference Laboratory and

has been supported by the Centers for Disease Control and Prevention (CDC) since 2001. This facility is

responsible for quality control and quality assurance of TB microscopy and culture and drug susceptibility

testing for all sites in Zambia.

In April 2006, the recently renovated administrative office for the CDC and CDL staff opened. This

renovation has provided for more laboratory workspace in addition to extra room to accommodate

management and supervisory staff. The renovation has allowed the CDC's technical laboratory experts to

provide frequent on-site training and mentoring support to the national laboratory staff. In addition, having

the CDC technical laboratory experts housed in the same compound allows for frequent supervision and

monitoring of equipment. CDL is also supported through the national TB program funded by the Global TB

Fund and has a long working relationship with the Zambart Project supported by the Bill and Melinda Gates

Foundation. Currently, the laboratory has two rapid TB culture systems provided through this project. The

Zambart Project also provides technical support and human resource capacity to the national TB laboratory

staff. As a result of this support, CDL is well equipped to provide technical assistance to provincial and

district laboratories. Contributions from the United States Government (USG), Zambart and the Gates

Foundation complement support to the National CDL provided from TBCAP, the Global Foundation, and

Churches Health Association of Zambia.

In FY 2007, this activity supported training for district laboratory staff in four provinces: Southern, Eastern,

Western and Lusaka. This complemented a similar training provided to districts in the remaining five

provinces by the Tropical Diseases Research Center (TDRC) in Ndola.

A national quality assurance (QA) system is expanding to improve the quality of diagnosis of TB in HIV-

positive individuals. This includes frequent supervisory visits, blind rechecking of acid-fast bacilli (AFB)

smears selected randomly, and proficiency testing of laboratory technicians using a standard panel of AFB

smears. By the end of FY 2007, 15 additional laboratory staff members were trained on the use of bio-

safety cabinets and techniques for improving laboratory infection control, while 20 staff members were

trained on the use of the fluorescent microscope. Other services included Gen Probe DNA technology

training for rapid TB identification and courier service twice per week to the national reference laboratory to

enhance test result turnaround time.

In FY 2008, the USG will continue to support the laboratory human resource capacity building for external

quality assurance of smear microscopy. CDC is supporting the validation of rapid first-line drug

susceptibility testing, and other support will include the following activities: 1) improvement of human

resource capacity by the placement of extra staff in the laboratory to properly perform national quality

assurance activities and give timely feedback to laboratories within the laboratory network; 2) procurement

of computers, training of laboratory staff, and continued support to maintain the local area network within

the laboratory to ensure continued access to Internet facilities and the ability to communicate with the

Ministry of Health (MOH) and other provincial and district centers within the country; 3) training of 260

laboratory staff participating in culture and external quality assurance program to support HIV care and

treatment.

USG is working closely with the national reference laboratory, MOH and other cooperating TB laboratory

partners to establish a TB Laboratory Coordination Committee to synchronize and strengthen training and

other activities in the TB network.