Detailed Mechanism Funding and Narrative

Years of mechanism: 2014 2015 2016 2017 2018 2019 2020

Details for Mechanism ID: 17705
Country/Region: Uganda
Year: 2014
Main Partner: Makerere University John Hopkins University Collaboration
Main Partner Program: NA
Organizational Type: University
Funding Agency: HHS/CDC
Total Funding: $500,000 Additional Pipeline Funding: N/A

NOTE: The following is taken from summaries released by PEPFAR on the PEPFAR Data Dashboard. They are incomplete summary paragraphs only and do not contain the full mechanism details. When the full narratives are released, we will update the mechanism pages accordingly.

The Makerere University-Johns Hopkins University Research Collaboration (MU-JHU) began in 1988 as a collaboration to conduct research in the areas of prevention of mother to child HIV transmission and paediatric clinical trials in resource limited settings. MUJHU has conducted multiple perinatal HIV prevention trials including the landmark HIVNET 012 trial whose results were incorporated into WHO and MOH PMTCT guidelines for resource-limited settings around the world. Paediatric treatment trials have included the IMPAACT study P1060 which compared a Nevirapine (NVP) based versus a Lopinavir/ ritonavir based antiretroviral regimen in HIV infected children who were exposed and not exposed to NVP at birth. The results of this study informed the WHO paediatric HIV treatment guidelines for resource limited settings. MUJHU, working with the NIH MTN network have recently completed the VOICE trial using antiretroviral drugs oral tablets/microbicides to reduce heterosexual transmission and are conducting the ASPIRE study using antiretroviral vaginal ring to reduce HIV transmission.

Since 2000, MU-JHU successfully supported the Mulago Hospital PMTCT Program where over 33,000 antenatal attendees receive same-day HIV screening annually. The PMTCT program has reduced infant infection rates to <5% at 6-12 weeks. In addition, since 2003 MUJHU has provided care and antiretroviral treatment for over 800 individuals, including 250 children enrolled in the MTCT plus family based comprehensive HIV care and treatment program.

In COP 2014, MUJHU will conduct a birth defects surveillance study in Mulago Hospital.

Mechanism Allocation by Budget Code for Selected Year
Biomedical Prevention: Prevention of Mother to Child Transmission (MTCT) $229,722
Treatment: Adult Treatment (HTXS) $270,278
Mechanism Target Information

Since COP2014, PEPFAR no longer produces narratives for every mechanism it funds. However, PEPFAR has now included performance targets or indicator information for each mechanism based on the Monitoring, Evaluation, and Reporting (MER) system. The MER guidance is available on PEPFAR's website https://www.pepfar.gov/reports/guidance/. Note that COP years 2014-2015 were under a previous version of the MER system and the indicators and definitions may have changed as of the new 2.0 guidance.

This mechanism has no published performance targets or indicators.

Key Issues Identified in Mechanism
Child Survival Activities
Safe Motherhood