Detailed Mechanism Funding and Narrative

Years of mechanism: 2011 2012 2013 2014 2015 2016 2017 2018

Details for Mechanism ID: 12981
Country/Region: Uganda
Year: 2011
Main Partner: Not Available
Main Partner Program: NA
Organizational Type: NGO
Funding Agency: HHS/CDC
Total Funding: $0

1. Overall goals and objectives

The 2nd National Health Policy (NHP II, 2011 - 2020) includes language addressing the need to provide and maintain functional, safe, environment friendly and sustainable health infrastructure including laboratories and waste management facilities. As part of the MOH structural reform, health laboratory services appear for the first time as a Division within the Department of Diagnostic Services emphasizing the importance MOH places on ensuring comprehensive, high-quality laboratory services throughout the country. PEPFAR has supported the establishment of an HIV Reference Laboratory at the Uganda Virus Research Institute (UVRI) and the maintenance of a national quality assurance (QA) program focused specifically on HIV-related testing. In order to continue supporting and strengthening this activity in government, private and non-government organizations, funding to continue and expand this service will be competed in 2011. Specific activities will include; quality control testing of a representative number of serum samples from newly enrolled field sites; distribution of proficiency testing (PT) panels to participating sites, GIS mapping of all static, participating sites in the country and documentation of human and other available resources at the sites as well as performance in QA activities. Working closely with the MOH Quality Assurance Unit, the Central Public Health Laboratory, the African Field Epidemiology Network (AFENET) and other partners, the successful grantee will provide, technical assistance, quality assurance/control to blood banks, national HIV surveys, VCT, PMTCT, RCT and other programs in both the public and private sectors. REDACTED. There will also be funding to validate new HIV tests and testing algorithms, to prepare proficiency testing panels and to establish and maintain a specimen repository. Staff at the HIV Reference Laboratory will be given both management and technical training as well as training in bio-safety/security. Once trained, staff will be facilitated to provide training to staff at health laboratories across the country following the WHO/CDC Training Manual. PEPFAR has also supported the creation and maintenance of the National HIV Drug-Resistance

Secretariat at UVRI. This unit is responsible for preventing and monitoring the emergence of drug- resistance to the ARV regimes in current use in the country. There are a number of laboratories in the country, including the national HIVDR laboratory at UVRI, with the capacity to conduct molecular analysis of drug-resistance strains arising in the country and the Secretariat coordinates this activity. Prevention of drug-resistance is achieved by continuous monitoring of the practices around ART and this is monitored by periodic assessment of early warning indicators (EWIs) as well as surveys of transmitted drug- resistance in newly-infected people. Where practices fall short of national standards for ART delivery, corrective actions are taken. HIVDR activities complement those of the national HIV QA testing program ensuring that newly-arising drug-resistant strains of HIV can still be detected by the national HIV serologic testing algorithm.

2. Target populations and geographic coverage

This program provides national support for QA activities and reaches all districts

3. Enhancing cost effectiveness and sustainability

Evidence of the cost-effectiveness of the national HIV testing program is obtained through continuous monitoring of the performance of facilities and organizations conducting HIV serologic testing. In addition, evaluation of new HIV tests and testing algorithms and subsequent adoption by ACP/MOH ensure that the overall national HIV testing program remains cost-effective and is able to detect all variants of HIV in circulation. Sustainability will be achieved as government progressively takes on more financial responsibility for procurement of commodities - the human resource to make this activity sustainable is being developed

4. Health Systems Strengthening The project will support the development of a small, effective QA unit for HIV serologic testing. Over time, QA activities for other HIV/AIDS-related laboratory services will be introduced. Through the PT program, capacity will be built in the districts that will ensure high-quality HIV testing services are available to all.

5. Cross-Cutting Budget Attributions

HIV serologic testing is the foundation on which the PEPFAR response to HIV/AIDS is built. Thematic

areas include SI, CT and laboratory. No budget attributions can be allocated at this time

Funding for Testing: HIV Testing and Counseling (HVCT): $0

None

Funding for Strategic Information (HVSI): $0

None

Funding for Laboratory Infrastructure (HLAB): $0

1. Target populations and coverage of target population or geographic area This program provides national support for QA activities and reaches all districts

2. Description of service delivery or other activity carried out

The 2nd National Health Policy (NHP II, 2011 - 2020) includes language addressing the need to provide and maintain functional, safe, environment friendly and sustainable health infrastructure including laboratories and waste management facilities. As part of the MOH structural reform, health laboratory services appear for the first time as a Division within the Department of Diagnostic Services emphasizing the importance MOH places on ensuring comprehensive, high-quality laboratory services throughout the country. PEPFAR has supported the establishment of an HIV Reference Laboratory at the Uganda Virus Research Institute (UVRI) and the maintenance of a national quality assurance (QA) program focused specifically on HIV-related testing. In order to continue supporting and strengthening this activity in government, private and non-government organizations, funding to continue and expand this service will be competed in 2011. Specific activities will include; quality control testing of a representative number of serum samples from newly enrolled field sites; distribution of proficiency testing (PT) panels to participating sites, GIS mapping of all static, participating sites in the country and documentation of human and other available resources at the sites as well as performance in QA activities. Working closely with the MOH Quality Assurance Unit, the Central Public Health Laboratory, the African Field Epidemiology Network (AFENET) and other partners, the successful grantee will provide, technical assistance, quality assurance/control to blood banks, national HIV surveys, VCT, PMTCT, RCT and other programs in both the public and private sectors. REDACTED. There will also be funding to validate new HIV tests and testing algorithms, to prepare proficiency testing panels and to establish and maintain a specimen repository. Staff at the HIV Reference Laboratory will be given both management and technical training as well as training in bio-safety/security. Once trained, staff will be facilitated to provide training to staff at health laboratories across the country following the WHO/CDC Training Manual. PEPFAR has also supported the creation and maintenance of the National HIV Drug-Resistance Secretariat at UVRI. This unit is responsible for preventing and monitoring the emergence of drug- resistance to the ARV regimes in current use in the country. There are a number of laboratories in the country, including the national HIVDR laboratory at UVRI, with the capacity to conduct molecular analysis of drug-resistance strains arising in the country and the Secretariat coordinates this activity. Prevention of drug-resistance is achieved by continuous monitoring of the practices around ART and this is monitored by periodic assessment of early warning indicators (EWIs) as well as surveys of transmitted drug-resistance in newly-infected people. Where practices fall short of national standards for ART delivery, corrective actions are taken. HIVDR activities complement those of the national HIV QA testing program ensuring that newly-arising drug-resistant strains of HIV can still be detected by the national HIV serologic testing algorithm.

3. Integration with other health activities

Participation in the HIV QA scheme promotes good laboratory practice for all laboratory activities

4. Relation to the national program This is the national program

5. Health Systems Strengthening and Human Resources for Health The project will support the development of a small, effective QA unit for HIV serologic testing. Over time, QA activities for other HIV/AIDS-related laboratory services will be introduced. Through the PT program, capacity will be built in the districts that will ensure high-quality HIV testing services are available to all.