Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 11138
Country/Region: Zambia
Year: 2009
Main Partner: University of Nebraska
Main Partner Program: NA
Organizational Type: University
Funding Agency: HHS/NIH
Total Funding: $280,000

Funding for Care: Pediatric Care and Support (PDCS): $280,000

THIS ACTIVY IS A CONTINUATION ACTIVITY UNDER LABORATORY AND IS BEING INCLUDED IN

THE PEDIATRIC SECTION. TARGTES WILL BE ROERTED UNDER LABORATORY SECTION.

This activity is linked to #8887, #8993, ART in Lusaka and the New Lab EID .

Reliable laboratory support continues to be critical for treatment and care of HIV/AIDS patients. This activity

in the past year has provided the University Teaching Hospital (UTH) Department of Pediatrics, with training

of laboratory personnel, equipment and supplies needed to perform Polymerase Chain Reaction (PCR)

diagnosis of HIV-exposed infants, viral load and HIV genotyping for the monitoring of drug resistance. The

training activity will continue for UTH but the support for Kalingalinga's laboratory will no longer be needed.

To date over 15 lab technicians have been trained from the two facilities and are now performing PCR for

HIV testing, tuberculosis diagnosis, syphilis testing and HIV disease monitoring. Through US Government

(USG) funding UTH now has machines and performs PCR and drug resistance monitoring. Currently the lab

staff who have been trained are performing all the needed laboratory assays, but at the same time they are

providing technical assistance to personnel from other laboratories as needed. Our trained lab technicians

will further be trained when updated procedures or techniques are introduced. They will be trained by

personnel sent from Nebraska or be sent to Nebraska for further training as needed.

In FY 2009, funds will be used to focus mainly on performing viral load and genotype and testing services.

Currently, three lab techs are trained and genotyping is being performed in the laboratory. This test is now

available for monitoring of treated individuals with clinical and immunological failures. Over twenty cases

from UTH have been tested successfully and our preliminary results on 100 cases from sentinel

surveillance of drug naïve cases throughout the country has indicated that 5% of the cases are already

carrying potential drug resistance viruses. Therefore we are anticipating a higher demand of the tests as

more patients are being treated and more drug failure cases will be observed. Due to the extremely time

consuming nature of the genotyping test, an additional technologist and data entry clerk are required to be

hired and trained to support the viral load and genotyping as genotyping will be scaled up in the coming

year. One senior (MD/PhD) level laboratory coordinator is being recruited to lead this component of the

work. This individual has already been identified and will be returning to Lusaka after completing his current

training in Nebraska in Oct 2008. Technical expertise from this center will support laboratory infrastructure

development of other sites in Zambia if needed. Lessons learned from this activity in FY 2008 in setting up

the various tests, especially the viral load and genotyping, will be applied to expanding the activities to other

sites, such as the UTH Virology Laboratory and the Arthur Davison's Children's Hospital in Ndola if needed.

Initiating and scaling up viral load and ARV drug resistance monitoring at the government hospitals in

collaboration with the Ministry of Health allows these government institutions to build national capacity

through acquiring skills and equipment necessary to scale up and maintain a high standard of pediatric ART

care. Under this activity Zambians trained in FY 2009 will work with facilities in other provincial hospitals to

transfer their knowledge and skills on viral load and resistance monitoring activities so more children can

access treatment as well as build a sustainable pediatric treatment at the provincial levels.

New/Continuing Activity: Continuing Activity

Continuing Activity: 15620

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

15620 3701.08 HHS/National University of 7202 4142.08 NIH $280,000

Institutes of Health Nebraska

9015 3701.07 HHS/National University of 5013 4142.07 NIH $280,000

Institutes of Health Nebraska

3701 3701.06 HHS/National University of 4142 4142.06 $280,000

Institutes of Health Nebraska

Emphasis Areas

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $40,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.10:

Cross Cutting Budget Categories and Known Amounts Total: $40,000
Human Resources for Health $40,000