Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 12348
Country/Region: Vietnam
Year: 2010
Main Partner: Not Available
Main Partner Program: NA
Organizational Type: NGO
Funding Agency: HHS/CDC
Total Funding: $0

Funding for Care: TB/HIV (HVTB): $0

May 2010 Programming = REDACTED

People with HIV who develop active TB are less likely to have sputum smears positive for acid-fast bacilli and less likely to

have typical chest x-ray findings, the two mainstays of diagnosis in Vietnam as in most TB high-burden countries. In

Vietnam, a recent TB prevalence survey identified a much lower than expected case detection rate (54%), which may be in

part related to low rates of diagnosis of smear-negative TB. The recognized limitations of smear microscopy for TB

diagnosis, particularly among PLHA, have led to many new diagnostic methods being developed and promoted in the last

several years. However, these methods are more expensive and require more technical expertise to use compared to

current approaches. A critical need for national TB and HIV programs is to identify how much benefit these new assays

provide in increasing diagnosis rates, which kind of patients benefit most, and how feasible they are to implement at

different levels of the healthcare system.

One particularly promising method is the "loop-mediated isothermal amplication" or LAMP assay which is significantly

cheaper and simpler to use than traditional PCR-based methods, and is intended to be used at peripheral laboratories. We

propose to work with the NTP to implement the LAMP test in 3-5 sites at different levels of the laboratory network. TB

suspect patients would have standard diagnostics according to routine care (smear microscopy and chest x-ray) in

addition to liquid-based culture (gold standard) and the LAMP test on sputum. Objectives are to assess the feasibility of

implementation at different levels of the laboratory network, and to assess the additional diagnostic yield of the LAMP test

compared to current routine tests in various patient populations, in particular PLHA. The project is expected to take 3 years

from preparation phase through implementation and evaluation.