Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 5102
Country/Region: Vietnam
Year: 2007
Main Partner: National Institute for Hygiene and Epidemiology - Vietnam
Main Partner Program: NA
Organizational Type: Host Country Government Agency
Funding Agency: HHS/CDC
Total Funding: $1,279,474

Funding for Laboratory Infrastructure (HLAB): $819,474

This activity is linked to HVCT FHI (9508), HVCT MOH/VAAC (9511), MTCT MOH (9384), HVSI NIHE (9244), and HLAB MOH/VAAC (9505).

PEPFAR will continue to fund the National Institute of Hygiene and Epidemiology (NIHE) for diverse ongoing activities related to strengthening laboratory infrastructure including: the development of an algorithm for use of rapid test kits for HIV diagnosis in controlled and field settings, monitoring of HIV drug resistance in Haiphong and Hanoi, expansion of infant diagnosis for HIV to 2 additional northern provinces, training of laboratory technicians in Quality Assurance (QA), provision of service contracts and hiring 2 temporary contractual staff to oversee the national EQA program in the diagnostic laboratory network.

Algorithm for HIV Diagnosis: In FY07 PEPFAR will support NIHE to use results from the FY06 rapid test assessment and to field test the proposed algorithm in both controlled and field environments in a total of 4 high and low HIV prevalence settings. Results of the analysis and recommendations for rapid testing algorithms will be used to advocate for MOH/VAAC approval of rapid testing for HIV diagnosis in Vietnam.

Patient monitoring for drug resistance: In FY07 NIHE will receive PEPFAR support for monitoring drug resistance in ARV patients in PEPFAR-supported outpatient clinics (OPC) in HCMC, which is a high-prevalence region. This activity is a part of enhanced patient monitoring and will be coordinated with the PEPFAR Strategic Information team in Vietnam and the HIV drug resistance unit at WHO Geneva. NIHE will sequence and analyze the specimens at the diagnostic National Reference Laboratory at Hanoi.

Infant Diagnosis: With PMTCT being a major component of PEPFAR activities, approval is being sought from VAAC to use Roche Amplicor DNA PCR 1.5 as an HIV diagnostic test for infants which will allow diagnosis and appropriate treatment and care at an early stage. In anticipation of this approval, NIHE has been designated as the prime partner for this activity. HHS/CDC Atlanta will support training for the test and provide external quality assessment and quality control panels to ensure ongoing validity of the test results. PEPFAR will support diagnosis in 344 infants at NIHE. NIHE will be responsible for continuation of this activity in Hanoi, Quang Ninh and Haiphong provinces and expand to Lan Son and Thai Nguyen provinces in FY07.

Training: In FY06 PEPFAR supported NIHE to conduct training for laboratory technicians in 20 provinces in northern Vietnam in QA with special emphasis on preventive maintenance of laboratory equipment. In FY07 PEPFAR will fund NIHE to provide similar training to 70 laboratory technicians in 35 southern and central provinces. This training will include demonstrations of preventive maintenance on laboratory equipment by different vendors.

Service Contracts: PEPFAR will provide funds to NIHE for service contracts for biosafety hoods and pipettes for the diagnostic laboratory network.

EQA program: NIHE will receive PEPFAR support for contracting 2 laboratory technicians to provide oversight for the national External Quality Assessment (EQA) program at 101 HIV diagnostic laboratories through site visits and data analyses. Human resources: PEPFAR will fund 2 laboratory technicians to support all the activities funded in FY07.

Significant cost savings have been realized from drop in ARV drug prices due to the availability of fixed dose combinations and decrease in price of second line drugs.

Funds will support capacity building of the HIV National Reference Laboratory (NRL) at the National Institute of Hygiene and Epidemiology (NIHE) in Hanoi. Funds will be allocated towards: 1) Technical assistance, alteration and renovation of the national reference lab for HIV in Hanoi 2) Capacity building, techinical assistance quality assurance and external quality assurance for the existing HIV RNA activities; 3) Expansion of monitoring for HIV drug resistance as per the WHO resistance monitoring protocol in 2 additional treatment sites to support resistance surveillance in 4 sites in total.

Funding for Strategic Information (HVSI): $460,000

This activity is linked to HLAB HCMC-PAC (9503), HLAB HSPH (9504), HLAB MOH/VAAC (9505), and HLAB APHL (9499).

NIHE heads Vietnam's HIV/AIDS surveillance subcommittee and has contributed to the national strategy by conducting surveillance and population-based surveys. In FY07, NIHE will focus on strengthening the national sentinel surveillance system and conducting surveillance among clients of CSW for behavioral data and among ART patients for drug resistance.

The details and estimated costs of proposed activities are as follows: 1. Sentinel Surveillance - $160,000. NIHE will implement national sentinel surveillance among 6 target populations: IDU, CSW, pregnant women, TB patients, STI patients, and military recruits in 40 provinces. In FY06, with TA from USG to strengthen the national HIV sentinel surveillance system, NIHE is conducting a pilot project to improve sampling and data quality among IDU and CSW using respondent driven sampling (RDS). If MOH/VAAC adopts the RDS methodology as standard protocol for national HIV sentinel surveillance, FY07 funds will be used to implement RDS among IDU and CSW. Otherwise, funds will be used to improve provincial capacity for implementing the existing convenient sampling, strengthening national capacity for supervision and conducting data quality oversight. Funds will also be used to strengthen facility-based sampling of pregnant women and TB and STI patients.

2. Behavioral Surveillance of CSW Clients - $50,000. Limited information is available for prevention programs seeking to reach clients of commercial sex workers. NIHE will conduct a special survey to obtain behavioral risk information on clients of sex workers in 2 provinces that will assist the MOH to tailor prevention programs to appropriately address risk behavior of clients and the resulting risk to sex partners.

3. Drug Resistance Surveillance - $100,000. To help ensure quality care and treatment services, HIV drug resistance genotyping will be completed for patients on ART at 2 sites. Patients enrolled in enhanced patient monitoring will be tested in order to determine underlying factors for drug resistance. Enhanced patient monitoring applies longitudinal surveillance to monitor outcomes which could link HIV drug resistance to factors such as risk behaviors and regimen adherence and change.

4. Technical Support for National Monitoring and Evaluation Activities - $0. NIHE will continue to support VAAC in operationalizing the national M&E framework using the previous fiscal year funds. In collaboration with the M&E unit in VAAC, NIHE has established a set of national core indicators and is establishing surveillance and M&E units located at the central, regional, and provincial level. NIHE will provide on-going M&E training and technical assistance to provinces in FY 2007.

This activity will support the provision of TA to NIHE and 40 surveillance sites and training for 82 implementing staff. Additional funds ($150,000) will allow rapid procurement of test kids for IBBS in 3 additional provinces. There is currently no funding for IBBS in NIHE's budget.