Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 4807
Country/Region: Uganda
Year: 2007
Main Partner: Uganda Virus Research Institute
Main Partner Program: Medical Research Council of Uganda--Uganda Virus Research Initiative Uganda Research Unit on AIDS
Organizational Type: Host Country Government Agency
Funding Agency: HHS/CDC
Total Funding: $700,000

Funding for Treatment: ARV Drugs (HTXD): $150,000

This activity also relates to 8331-Strategic Information.

The Medical Research Council (MRC) has worked in Uganda since 1989 conducting population-based evaluations in conjunction with the MOH and other partners to inform the control of the HIV/AIDS epidemic and its consequences. For example, in collaboration with the Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine MRC is currently conducting large-scale field trails on HIV-prevention strategies and ARV therapy approaches. As part of this, they have over 40 clusters, defined as groups of communities being evaluated. In late FY04 a partnership between MRC, CDC and TASO was established to conduct an evaluation to compare facility- and home-based ART service delivery systems. The study population comprises 1000 current TASO clients served in the Jinja District branch. During that time the study protocol was developed and approved, and systems to begin data collection were designed. In FY05 activities focused on training TASO health care providers in delivering ART services to clients using both the facility-based and home-based service delivery models; the enrollment of clients for the evaluation; initial client registration data collection; an analysis of the existing TASO services and data for the clients enrolled. In FY06, MRC through a sub-partner agreement with TASO provided funding to procure ARTs and other related OI drugs for the 1,000 clients recruited as part of the targeted evaluation.

In FY07 follow-up of clients on ART will continue and clinical, laboratory, social, economic and behavioral data will be recorded. The purpose of the evaluation is to follow the 1000 ART clients enrolled to measure the two service delivery models effectiveness and costs, client behavior and adherence and, family counseling and testing uptake. Other related MRC activities outlined in the strategic information section are to provide support and technical assistance to TASO's HMIS unit and assist TASO with the conduct of population-based client survey on behavior with treatment and adherence to the drug regime. The activity will strengthen TASO's capacity in the collection and interpretation of client and service delivery data to inform clinical services and program management. MRC/UVRI will also conduct the evaluation activities to compare the effectiveness of both strategies. The primary outcome indicator for this evaluation is the number of clients who experience treatment failure as measured by a viral load of >500 copies/microlitre after initial successful viral suppression. Other outcomes include treatment adherence and uptake of VCT services by clients' family members. Evaluation findings will be shared as appropriate to inform the national program and other provider on the most effective approaches for clients to access HIV care and treatment in resource-limited settings.

Funding for Strategic Information (HVSI): $550,000

This activity also complements activity 8332-ARV drugs. As ART is scaled up in Africa, policy makers will need to know how home-based and facility-based delivery systems are associated with treatment outcomes and the cost-effectiveness of each service delivery model. In late FY04 a partnership between MRC, CDC and TASO was established to conduct an evaluation to compare facility and home-based ART service delivery systems. The study participants compromised 1000 current TASO clients at the TASO Jinja District branch. In early FY05, the study protocol was developed and approved, and systems to begin data collection were designed. Other FY05 activities focused on training TASO health care providers in delivering ART services to clients using both the facility-based and home-based service delivery models; the enrollment of clients for the evaluation; initial client registration data collection; and, an analysis of the existing TASO services and data for the clients enrolled. In FY06, MRC worked with TASO and continued data collection and analysis according to the approved protocol. Clients were interviewed and specimens collected at baseline and at 6-month follow-up visits. In FY07, MRC will continue follow-up of clients to record clinical events, collect data on service delivery model and patient costs, client behavior and adherence, family counseling and testing and collect specimens for analysis. Follow-up visits will occur at 6-monthly intervals. This will all be done according to the approved protocol. In addition MRC will provide support and technical assistance to TASO's HMIS unit and assist TASO with the conduct of population-based client survey on behavioral aspects of treatment and adherence to the drug regime. The activity will strengthen TASO's capacity in the collection and interpretation of client and service delivery data to inform clinical services and program management. MRC will also conduct the evaluation analysis activities to compare the cost effectiveness of both strategies. The primary outcome indicator for this evaluation is the number of clients who experience treatment failure as measured by a viral load of >500 copies/microlitre after initial successful viral suppression. Other outcomes include treatment adherence and uptake of VCT services by clients' family members. Evaluation findings will be shared to inform the national program and other providers on the most effective approaches for clients to access HIV care and treatment in resource-limited settings.

Subpartners Total: $150,000
The AIDS Support Organization: $150,000