Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 7532
Country/Region: Kenya
Year: 2009
Main Partner: To Be Determined
Main Partner Program: NA
Organizational Type: Implementing Agency
Funding Agency: HHS/CDC
Total Funding: $0

Funding for Treatment: Adult Treatment (HTXS): $0

ACTIVITY HAS BEEN MODIFIED IN THE FOLLOWING WAYS FROM COP 2008:

+ The Prime Partner has changed from KEMRI to TBD.

COP 2008

WHO and CDC have developed a method to monitor the emergence of HIV drug resistance (HIVDR) during

the first year of antiretroviral treatment (ART) and evaluate potentially associated program factors which

could be altered to optimize ART program functioning for HIVDR prevention. A sample size of

approximately 100 patients initiating ART is evaluated at baseline and 12 months at 3-5 sentinel sites. At

baseline, a genotype and brief ARV history are taken. At 12 months, or at time of switch to a second-line

regimen, a viral load (VL), a genotype, and an adherence assessment are performed. Monitoring is defined

as the measurement and interpretation of viral suppression in populations taking first-line ART 12 months

after commencement of ART and the measurement and interpretation of HIVDR in populations commencing

ART and in populations not achieving viral suppression after 12 months of first-line ART. Data will assist the

Kenya Ministry of Health National AIDS and STI Control Program (NASCOP) and other national and

international partners to design strategies to improve ART outcomes and support recommendations for

optimal first- and second-line regimens and indications for time of regimen switch. This strategy will be

implemented along with early warning indicators available from routine ART clinical data. The sentinel

methodology will be incorporated as a routine evaluation. The completion of surveillance and data

collection using COP 08 funding is anticipated. Additional funding is requested in FY09 COP for data

analysis and report writing.

New/Continuing Activity: Continuing Activity

Continuing Activity: 17154

Table 3.3.09: