Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 13930
Country/Region: Ethiopia
Year: 2013
Main Partner: Ministry of Health - Ethiopia
Main Partner Program: Ethiopian Health and Nutrition Research Institute
Organizational Type: Host Country Government Agency
Funding Agency: HHS/CDC
Total Funding: $1,250,000

This is a new award / mechanism with single eligibility for the Ethiopian Health and Nutrition Research Institute (EHNRI), which has a leadership role for national laboratory services, coordination, implementation and knowledge transfer for health-related research, survey and surveillance activities and public health emergency management. EHNRI has established a 5 year integrated laboratory master plan (2009-2013). Guided by this plan, EHNRI will provide standardization of lab services, targeted training programs, integration of services, regional lab capacity development, improvement of commodity procurement and distribution, strengthening and expansion of national lab quality systems, equipment maintenance services, lab networking and sample referral, deployment of data management system, lab workforce development, mentorship and evaluation of better technologies. EHNRI also provides guidance for establishment and implementation of lab accreditation including the WHO/AFRO accreditation. Strategic information is crucial. There is a need to generate accurate and timely estimates of trends in prevalence, incidence, MARPS, and the impact of interventions. EHNRI developed a 5 year (2010-2014) strategy for HIV surveillance, currently being implemented. EHNRI requires considerable capacity building support from PEPFAR to operationalize this strategy. EHNRI produced a report for the 2009 ANC-based HIV surveillance and played an important role in DHS+, which is in its final stage of completion. TB/HIV surveillance has been completed in 35 sentinel sites and preparation is underway to conduct the second round. Data collection will start soon for MARPS, STI syndromic and etiology based surveillance, and TB drug resistance survey.

Funding for Care: TB/HIV (HVTB): $181,864

In FY2011, EHNRI launched the second round of national anti-TB drug resistance surveys at 32 sites. This survey will determine the prevalence and pattern of anti-TB drug resistance among HIV co-infected TB patients as a sub-component. Preparations are underway and survey materials, supplies and data collection guidance and tools have been distributed. A sensitization workshop has been held to ensure collaboration and smooth implementation. EHNRI has established six TB culture facilities at regional labs and MDR treatment hospitals. The capacity building support involves major renovation, negative pressure installation and furnishing of the laboratories. Under COP2012, EHNRI will continue to support the second round of the drug resistance survey by providing refresher training, supportive supervision, undertake review meetings, support data entry and printing and dissemination of the report. EHNRI will make all necessary preparations including site assessment and selection, material procurement, and training for the third round drug resistance survey which also includes second line drug resistance testing to determine the prevalence of XDR-TB. A drug resistance survey will also be conducted among prison populations at selected sites. TB culture and DST including molecular technique will be expanded to two regional laboratories. EHNRI will expand GeneXpert MTB/RIF to high case load facilities. Resources will be coordinated with the Global fund to buy GeneXpert equipment, calibration and training. EHNRI will work with regional labs for quantification, procurement and maintenance of constant supply for AFB and fluorescent microscopy, culture and DST and molecular diagnostic services. EHNRI will work with regional laboratories to strengthen the laboratory network for TB diagnosis, establish integrated sputum transportation, scale up of TB microscopy EQA to more sites, prepare panels for TB EQA, and make regional visits. EHNRI in collaboration with HHS/CDC will introduce AFB microscopy EQA management software for panel and blinded rechecking.

Funding for Laboratory Infrastructure (HLAB): $821,444

This is a continuing activity from a previously ended agreement. Preventive and curative equipment maintenance plays a critical role in ensuring quality laboratory testing. EHNRI has developed a comprehensive equipment maintenance strategy incorporating issues related to equipment management in line with the Maputo Declaration. In FY2011, EHNRI maintenance engineers provided curative maintenance services for ART monitoring instruments. Several spare parts were procured for repair and scheduled maintenance of ART equipment. Recently, EHNRI has started to engage RHBs to decentralize equipment maintenance roles to the regions. Under COP2012, EHNRI will continue building local capacity for the preventive and curative maintenance of major and ancillary equipment. Capacity for certification of biosafety cabinets will be established at the central level. Purchase of spare parts and tools for the local engineers will continue to build regional equipment maintenance capacity. Maintenance service agreements will be established with vendors. EHNRI will work with other agencies in MOH to harmonize and implement equipment management policies. EHNRI has supported the implementation of LIS in 10 sites. Currently, an evaluation is being conducted and discussions are undergoing to integrate LIS with EMR. Under FY2012, LIS will be expanded to selected facilities. Integrated external quality assurance activity has been expanded to more sites. EHNRI will continue to expand the national EQA to more sites with special emphasis on regional capacity building to run regional EQA. The WHO/AFRO step-wise laboratory accreditation was implemented in 39 laboratories. Under COP2012, 52 laboratories will be enrolled. For sample referral, there is an agreement with the Ethiopian Postal System for DBS nationally and for all samples in Addis and some sites in Amhara region. This will be further strengthened with addition of TB and viral load samples. Microbiology laboratory service will be strengthened and there will be ongoing evaluation of better diagnostic technologies for local adaptation.

Funding for Strategic Information (HVSI): $246,692

In prior years, EHNRI conducted ANC-based HIV surveillance in 115 sentinel sites. The report has been recently released. Assessment of PMTCT program data has been done in 43 selected PMTCT/ANC sites which helped in understanding of data quality, uptake of HIV testing and completeness of information. EHNRI has also developed TB/HIV surveillance system which was successfully implemented in 27 sites. The system generated important information on seven indicators of TB/HIV and will be expanded to more than 110 new priority sites. The STI etiologic and syndropmic surveillance system has been finalized. EHNRI will implement the 2012 round of ANC-based HIV surveillance in 134 sites and will also evaluate the BED assay to estimate recent HIV infection. PMTCT data assessment will also be done on 80 ANC/PMTCT sites immediately after ANC surveillance. This will help track improvements in the uptake and data quality from PMTCT program. EHNRI will also provide TOT for national and regional TB/HIV and STI surveillance activities with periodic site supervision. Regions and sentinel sites will be supported in data collection, analysis and use. EHNRI will continue to collaborate with HHS/CDC and WHO to strengthen the HIV drug resistance surveillance system. This includes carrying out the early warning indicator survey for patients on ART, a drug threshold survey on HTC/ANC clients and prevention cohort monitoring on newly enrolled ART clients in at least four sites. EHNRI will also support initiating the missing components of HIV surveillance including case surveillance and pediatrics HIV surveillance in Ethiopia.