Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 5017
Country/Region: Zambia
Year: 2007
Main Partner: Tropical Diseases Research Centre
Main Partner Program: NA
Organizational Type: Parastatal
Funding Agency: HHS/CDC
Total Funding: $640,000

Funding for Laboratory Infrastructure (HLAB): $190,000

This activities is linked to #8993, #8991.

Since 2004, the Tropical Diseases Research Centre's (TDRC) tuberculosis (TB) Regional Reference Laboratory has provided acid fast bacilli (AFB) smear microscopy services for the Ndola area. However, in 2004/5 the United States Government provided funding to upgrade the lab to a "state-of-the-art" facility to support the scale-up of HIV/TB activities. The renovation is complete and the center opened in May 2005, now provides TB fluorescent microscopy and expanded TB culture services for People Living with HIV/AIDS (PLWHA) in the northern region of the country. TDRC supports cultures from five provinces encompassing forty two districts. In addition to renovation, this activity has provided training to personnel for lab support, procure basic laboratory equipment, reagents and supplies for TB culture, and drug susceptibility testing capacity. Training was provided to ten staff on bio-safety and preparation of reagents culture media. Equipment provided includes a BACTEC MGIT TB culture system, in addition to a water tank, and generator for electricity backup.

The diagnosis of TB in HIV-positive cases is often difficult in rural settings without specialized equipment. Therefore, it was necessary to establish a courier system for specimen transport from twelve chest clinics within five provinces which include the Copperbelt, Northern, Northwestern, Luapula, and Central. The laboratory work in collaboration with the National TB Reference Laboratory to improve rapid culture and drugs susceptibility diagnostic testing services. The laboratory also provides support to the Arthur Davison's Children's Hospital, which is the national Pediatric Hospital located a few kilometers from the TDRC. The TDRC is working very closely with the TB Country Assistance Program (TBCAP) working in three of the five Northern provinces including the Copperbelt, Northern, and Luapula Provinces.

In fiscal year 2007 the TDRC laboratory staff will be dedicated to improving detection of TB cases using liquid culture technology as well as supporting external quality assurance services in local and rural settings for AFB smear microscopy. These services will include training, proficiency testing, AFB smear microscopy rechecking, and feedback to the laboratories. Training will be provided to two technologists from each of the five provinces to expand capacity for supervision and monitoring of TB/HIV support in the district hospitals. The ten technologists are currently government staff who will receive further training to expand their laboratory technical role. Those trained at the provincial level will be expected to share skills with district staff during their supervisory visits to ensure laboratory silks are expanded and sustained at all levels of government health infrastructure. Funding will support expansion of TB culture supplies and drugs for TB drug susceptibility testing, DNA probe identification systems, validation of biosafety cabinets and other equipment as well as two air conditioners to support the operation of automatic blood culture systems in the UTH microbiology laboratory.

Funding for Strategic Information (HVSI): $450,000

This activity relates to Ministry of Health (MOH) (#9008), and Centers for Disease Control and Prevention (CDC) (#9023).

This cooperative agreement with the Tropical Diseases Research Centre (TDRC) was established with the following objectives: (1) to expand the use of quality program data for policy development and program management; (2) to support and increase TDRC expertise in the surveillance of HIV/AIDS/STI/TB; (3) to improve information and communication technology (ICT) infrastructure; (4) to improve human resource capacity for monitoring and evaluation (M&E); and (5) to strengthen capacity in scientific research methods, data management and statistical analysis, and reporting. Centers for Disease Control and Prevention (CDC)-Zambia will continue to provide technical assistance and other support to strengthen the TDRC and its infrastructure as a key partner in HIV/AIDS/STI/TB surveillance, laboratory and strategic information quality control and assurance, and strategic information. In fiscal year (FY) 07 CDC-Zambia will place special emphasis on training in ICT and data management/statistical analysis in order to strengthen TDRC expertise in these areas for sustainability of all above activities.

Funding to the TDRC will also cover travel and transportation needs for national surveillance activities, procurement of consumables in the immunology and data processing units, procurement of -70 freezers for storage of samples from national surveys, and expenses to cover the coordination, implementation, and dissemination of survey results. This activity will continue to maintain support of a local area network (LAN) established during fiscal year (FY) 2004. FY 2007 funding will allow increased bandwidth and the expansion of LAN coverage to the new tuberculosis (TB) laboratory supported by CDC-Zambia. FY 2007 funding will also help to procure ICT equipment, enable TDRC to continue the employment of personnel skilled in ICT to maintain the infrastructure, to provide in-house ICT expertise and training capability, and to train TDRC staff in data management.

An important component is that TDRC will support the Government of the Republic of Zambia (GRZ) HIV/AIDS, Sexually Transmitted Infections, and TB surveillance activities, including the Zambia Antenatal Clinic Sentinel Surveillance (SS) survey and the Zambia Demographic and Health Survey (ZDHS). TDRC also serves as the regional reference laboratory for HIV and syphilis testing for these and other national surveys. TDRC laboratory and data processing personnel have participated in multiple CDC-Zambia-sponsored training in SI and laboratory methods, and work closely with CDC-Zambia staff in data management, analysis, and reporting. TDRC laboratory staff was trained to perform the BED-CEIA assay and testing is currently ongoing for recent HIV infections to estimate HIV incidence. Laboratory staff will also perform HIV incidence testing, confirm syphilis testing, and perform HSV2 testing on specimens collected for the Nakambala Migrant Workers Health Project.

M&E activities for TDRC will focus on: (1) continued operation of the LAN and extension of LAN coverage to the newly completed TB laboratory; (2) the number of TDRC and District Health Center staff trained in SI; (3) the successful design and implementation of the SS and ZDHS in 2006; (4) the successful collection, storage, and management of demographic information and biologic specimens; (5) additional laboratory testing required for surveillance activities and focused studies such as the Nakambala Migrant Workers Health Study; (6) the appropriate analysis and reporting of HIV prevalence and incidence data in relation to socio-demographic data; and (7) the dissemination of surveillance information for GRZ planning, making of policy decisions, and design of community-level interventions.