Detailed Mechanism Funding and Narrative

Years of mechanism: 2008 2009

Details for Mechanism ID: 303
Country/Region: Kenya
Year: 2009
Main Partner: University of Nairobi
Main Partner Program: NA
Organizational Type: University
Funding Agency: HHS/CDC
Total Funding: $1,410,000

Funding for Biomedical Prevention: Prevention of Mother to Child Transmission (MTCT): $1,160,000

ACTIVITY HAS BEEN MODIFIED IN THE FOLLOWING WAYS FROM COP 2008:

+ Focus on PwP strategies to strengthen prevention activities

+ Support in the establishment of functional laboratory networks

+ Support to national quality assurance for HIV testing in PMTCT settings

SECONDARY CROSS-CUTTING BUDGET ATTRIBUTIONS

This activity supports key attributions in human capacity development through the training of health care

service providers on PMTCT and other HIV prevention and care topics in order to equip them with

knowledge and skills to provide quality PMTCT services. These service providers include Doctors, Nurses,

Clinical Officers, Nutrition Officers and Health Record clerks. This program also supports the pre-service

training of Doctors at the University of Nairobi Medical School.

COP 2008

1. LIST OF RELATED ACTIVITIES

This activity relates to University of Nairobi Department of Pediatrics ART Program; APHIA II Nairobi ART

Program; UCSF ART Program and TBD ART Program. All HIV-positive mothers, their infants and partners

who are eligible for treatment will be linked to the HIV/AIDS treatment and care services directly or through

referral.

2. ACTIVITY DESCRIPTION

UoN, Department of Obstetrics and Gynecology has been supporting implementation of comprehensive

PMTCT services in Kenyatta National Hospital (KNH) and Pumwani Maternity Hospital (PMH), the two

largest maternity units in the country and has successfully integrated these services as part of routine care

for all women accessing services here. In FY 08, UoN expanded geographical area of coverage to include

support of PMTCT activities in the districts of Nyando and Kisumu East in Nyanza province and supported

implementation of PMTCT in a total of 40 additional health facilities. In 2009 the program will continue to

support these activities in the same geographical area of focus, and will provide HIV counseling and testing

to a total of 51,024 (93%) of 54,625 pregnant women (21,469 in Nairobi, 16,147 in Kisumu East and 13,408

in Nyando District). All HIV-positive pregnant women shall have immunological and HIV clinical staging

done to identify the appropriate ARV prophylaxis regimen as per the national guidelines. The program will

target to provide a complete course of ARV prophylaxis to 7,818 (93%) of 8,370 HIV-positive pregnant

women. Of these HIV positive women 1,564 will be provided with Highly Active Antiretroviral Treatment

(HAART) and 3909 will receive the more efficacious ARV regimen of Zidovudine and Single Dose

Nevirapine (sd NVP) with the addition of 4 TC intrapartum and post natal period, while 2,345 will receive the

minimum intervention of sd Nevirapine. All HIV exposed infant will be given ARV prophylaxis in line with the

National PMTCT guidelines. The program will strengthen comprehensive PMTCT including couple

counseling and will target to reach at least 9,805 male partners with HIV counseling and testing services. To

improve the quality of life for HIV infected women, the program will wrap around other programs namely

Safe motherhood and Family planning as well as TB screening and linkage to treatment. In strengthening

the linkage between PMTCT and Pediatric HIV care services, the program shall support early infant HIV

infection diagnosis by use of Polymerase Chain Reaction (PCR) for 3,854 infants and link all eligible infants

to the pediatric ART program. The program shall strengthen the post natal HIV care clinic and shall support

at least 10 facilities in the Nyanza region to initiate this strategy. The program shall also work and

strengthen linkage with Child Survival activities to ensure that all infants and especially the HIV exposed

and infected access immunization, growth monitoring, safe water and Infant and Young Child feeding

services and support which will contribute to improved infant and child health outcomes. The mentor

mothers' initiative is another national effort aimed at improving Infant and Young Child Feeding especially

for the HIV exposed or infected child. The program will support the roll out of this strategy in at least 15

facilities in Nyanza. Improved access to laboratory services for HIV +ve women and their exposed infants is

an important step in ensuring accurate assessment for HIV care and treatment. The program will work with

the other PEPFAR funded partners, Ministry of Health and other implementing partners in establishing and

maintaining a functional laboratory network in the geographical area of focus. Intra-partum and immediate

post partum counseling and testing shall also be strengthened with a target of reaching 100% of all women

attending delivery services at the maternity units within the program area. Currently over 50% pregnant

women admitted in the labor and delivery units do not know their HIV status. The program will also promote

couple counseling and testing to identify discordant and concordant couples to improve primary prevention

and facilitate linkage to HIV care and treatment program for the eligible, in addition to strengthening

Prevention with Positives strategy. The program will support the training of 300 service providers on

PMTCT, Rationale use of ARVs, and Data collection and reporting in 42 facilities. In line with the capacity

building mandate of the UoN, the program in collaboration with NASCOP and DRH will facilitate a structured

platform for regular review of PMTCT research to inform and guide national PMTCT policy and practice.

Finally the UoN program will support the establishment and administration of a national Quality Assurance

system for HIV testing in PMTCT settings. Although the country has a national QA system for HIV testing in

the traditional VCT sites, the PMTCT program which conducts over 800,000 HIV tests annually in MCH and

maternity units does not have any QA system in place. In 2009 COP, the PMTCT program is targeting to

reach at least 1,300,000 million pregnant women with HIV testing and counseling services in the country. It

is therefore important to set up a system to improve validity of rapid testing in PMTCT sites as the test

results are used for decision making in the care and follow up of the women and their infants. This activity

will therefore be expanded to incorporate a QA for PMTCT testing program that will be implemented by the

Department of Microbiology, University of Nairobi. The department will work with the USG agencies,

laboratory partners and country representatives to implement the national strategic plans for laboratory

quality systems and ensure that laboratory testing is available, accurate, reliable and timely. As a starting

point the Department of Microbiology will train staff at PMTCT settings in good laboratory practice and QA in

HIV testing and haemoglobin measurement. Regular support supervision, proficiency and validation testing

will be established for PMTCT sites across the country. Workshops will be conducted to evaluate EQA

performance, and improve performance. The department will further support the national QA plan by

working in close collaboration with the CDC GAP laboratory National Public Health Laboratory Services.

The department is expected to leverage its expertise to development and use of standard operating

procedures for specimen tracking, testing procedures, results reporting, equipment maintenance and

inventory. A total of $260,000 has been set aside for this activity.

Activity Narrative: 3. CONTRIBUTIONS TO OVERALL PROGRAM AREA

PMTCT activities in these two high volume national referral facilities and Nyando and Kisumu East districts

will contribute to approximately 3.9% of 2009 overall Emergency plan PMTCT targets for Kenya and 9% of

ARV PMTCT prophylaxis. Strengthening HIV counseling and testing of women during labor and around

delivery will increase the number of HIV-positive women accessing HIV care services. Couple counseling

and testing will contribute to more men knowing their HIV status and those who are positive will be able to

access other HIV care services. This activity also contributes to expansion of pediatric HIV care and

treatment services.

4. LINKS TO OTHER ACTIVITES

This activity relates to University of Nairobi Department of Pediatrics ART Program; APHIA II Nairobi ART

Program; UCSF ART Program and TBD ART Program. All HIV-positive mothers, their infants and partners

who are eligible for treatment will be linked to the HIV/AIDS treatment and care services directly or through

referral.

5. POPULATIONS BEINGTARGETED

This activity targets Children less than 5 years, adolescents aged 15-24 years, adults, discordant couples,

people living with HIV/AIDS and pregnant women.

6. EMPHASIS AREAS/ KEY LEGISLATIVE ISSUES ADDRESSED

This activity will increase gender equity in HIV/AIDS programs through providing PMTCT services to

pregnant women and their partners. Other emphasis areas include capacity building through supporting in-

service training for providers on comprehensive PMTCT programming that addresses all the four prongs,

wrap around programs for family planning, malaria and safe motherhood through the provision of

comprehensive PMTCT package that addresses all these elements. The comprehensive PMTCT package

includes focused antenatal care that addresses safe mother hood issues, malaria prevention through the

provision of insecticide treated bed nets for the pregnant woman and intermittent presumptive treatment for

malaria, and increased access to family planning with a focus on dual method for the HIV-positive mothers.

New/Continuing Activity: Continuing Activity

Continuing Activity: 15033

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

15033 4147.08 HHS/Centers for University of 7017 303.08 Department of $1,100,000

Disease Control & Nairobi Obstetrics and

Prevention Gynecology

7097 4147.07 HHS/Centers for University of 4299 303.07 Department of $1,665,082

Disease Control & Nairobi Obstetrics and

Prevention Gynecology

4147 4147.06 HHS/Centers for University of 3224 303.06 Department of $600,000

Disease Control & Nairobi Obstetrics and

Prevention Gynecology

Emphasis Areas

Gender

* Addressing male norms and behaviors

* Increasing gender equity in HIV/AIDS programs

* Reducing violence and coercion

Health-related Wraparound Programs

* Family Planning

* Malaria (PMI)

* Safe Motherhood

Human Capacity Development

Estimated amount of funding that is planned for Human Capacity Development $81,000

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.01:

Funding for Biomedical Prevention: Prevention of Mother to Child Transmission (MTCT): $0

This PHE activity,"Evaluation of the Impact of the National PMTCT program in Kenya," was approved for

inclusion in the COP. The PHE tracking ID associated with this activity is KE.07.0057. A copy of the

progress report is included in the Supporting Documents section.

New/Continuing Activity: Continuing Activity

Continuing Activity: 17823

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

17823 17823.08 HHS/Centers for University of 7017 303.08 Department of $228,700

Disease Control & Nairobi Obstetrics and

Prevention Gynecology

Emphasis Areas

Human Capacity Development

Public Health Evaluation

Estimated amount of funding that is planned for Public Health Evaluation $0

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.01:

Funding for Sexual Prevention: Other Sexual Prevention (HVOP): $50,000

ACTIVITY UNCHANGED FROM COP 2008

1. LIST OF RELATED ACTIVITIES

This activity relates to activities in Counseling and Testing, Condoms and Other Prevention, Palliative care

and ARV services.

2. ACTIVITY DESCRIPTION

The Partners in Prevention (PiP) team, based out of the University of Nairobi, has a wealth of experience

with discordant couples that uniquely places them in a position to take on the activities highlighted below:

With supplemental funds received in FY08, this team was requested to build on their experience and

expertise with discordant couples to concretize a standardized set of tools and materials for use in

discordant couples' support groups at a national level. They were also charged to leverage a mix of OP and

CT funds to link counseling and testing to discordant couples support groups, enabling a smooth connection

between a positive test result and support provided by such support groups for both the positive and

negative partners. The materials will contain standardized information not only on psychosocial and

positive living issues but also on HIV prevention and broader Prevention with Positives (PwP) concepts to

benefit both the negative and positive partners in the discordant couple. The materials developed will

include curriculum and training manuals, as well as implementation materials including job aids. These

tools and resources should be used to promote consistent messages so that any discordant couple may

have access to standardized information and resources throughout Kenya. These materials will also feed

into the National PwP Working Group's mandate to create a comprehensive PwP Toolkit. The materials

created will serve as a toolkit for training peer educators in discordant couples' interventions. Following the

development of these materials, funds may be used to print and disseminate them, as well as to provide

training to peer educators so that standardized prevention interventions can be rolled out to discordant

couples' support groups throughout the country. Materials will be used to train 300 peer educators (from

each of PiP's existing discordant couples support groups in Nairobi (120), Eldoret (40), Thika (20) and

Kisumu (120)). These peer educators will then create linkages with family testing and home-based

counseling and testing (HBCT) interventions, as well as care and treatment sites, to provide standardized

peer education services and support to discordant couples. Additionally, technical assistance and support

will be provided to existing discordant couples groups to strengthen and standardize their prevention

interventions. Peer education and technical assistance sessions will ultimately reach 10,000 individuals.

Each of these peer educators will serve as condom outlets regularly supplying condoms to the support

groups with which they work, thus resulting in 300 new condom outlets.

3. CONTRIBUTIONS TO OVERALL PROGRAM AREA

The Kenya AIDS Indicator Survey (KAIS) has revealed that among married individuals who are HIV-

infected, 45% have a partner who is not currently infected; this amounts to nearly 400,000 discordant

couples in Kenya. The uninfected partner in a discordant relationship is at extremely high risk of infection,

and both members of the couple face unique needs that are not currently addressed in any systematic

manner. This activity enables the provision of quality and standardized prevention services to discordant

couples.

4. LINKS TO OTHER ACTIVITIES

These interventions will have a strong link to couples counseling and testing activities, including home-

based counseling and testing. OP and CT will leverage funds to ensure an integrated and standardized

approach, enabling a smooth linkage between a positive test result and support provided by such support

groups. Additionally, this activity will link with care and treatment programs so as to capture identified

discordant couples and related support groups. This activity will also link with activities of Discordant

Couples of Kenya, a sub-partner of CHF in FY08 and an anticipated sub-partner of the Umbrella TBD.

5. POPULATIONS BEING TARGETED

This activity will specifically target discordant couples in Kenya; this population comprises one of the most

highly vulnerable groups in the country. Discordant couples will be reached through existing discordant

couples' support groups as well as by identification through linkages with counseling and testing as well as

care and treatment sites. Discordant couples will then benefit from targeted prevention messages and

interventions designed by the team at University of Nairobi and rolled out through trained peer educators.

6. KEY LEGISLATIVE ISSUES ADDRESSED

The primary legislative issue is addressing gender equity, and reduction in stigma and discrimination in

HIV/AIDS programs.

7. EMPHASIS AREAS

This activity includes emphasis on quality assurance, curriculum development and training. Other activities

include production of information, education and communication.

New/Continuing Activity: Continuing Activity

Continuing Activity: 19436

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

19436 19436.08 HHS/Centers for University of 7017 303.08 Department of $50,000

Disease Control & Nairobi Obstetrics and

Prevention Gynecology

Emphasis Areas

Gender

* Increasing gender equity in HIV/AIDS programs

Human Capacity Development

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.03:

Funding for Biomedical Prevention: Injection Safety (HMIN): $100,000

ACTIVITY UNCHANGED FROM COP 2008

1. LIST OF RELATED ACTIVITIES

This activity is linked to other IS activities (#7010, #8824, #8821).

2. ACTIVITY DESCRIPTION This activity relates to the prevention of HIV transmission by medical injections

through acquisition of strategic information by the generation of a sound evidence base on injection

practices in a spectrum of health care facilities across the country including provincial, district and faith-

based hospitals, health centers, nursing homes and dispensaries. The University of Nairobi, Clinical

Epidemiology Unit (CEU) will implement this activity. CEU was established in 1989 within the College of

Health Sciences, University of Nairobi, and is a member of the International Clinical Epidemiology Network

(INCLEN), founded in 1980 with support from the Rockefeller Foundation. It is comprised of a team of

medical and public health specialists brought together by the common need of creating a pool of experts in

health research development. Its multidisciplinary nature permits the provision of a wide range of quality

services in health research, training, study design, data collection, data analysis and translation of research

findings into health action through policy change and practice. Two targeted evaluations will be conducted

by the CEU to determine: 1. Injection practices, factors that influence demand for injections, prescription of

injections and reuse of injection equipment in Kenya, injection use in the informal sector and the prevalence

of needle stick injuries. The direct and indirect cost of injectable therapy as compared to alternative routes

of medication will be determined with a view to advocating for rational injection use and review of national

treatment guidelines and Essential Drugs Lists. 2. Attitudes, beliefs and practices related to the use of

suppositories in Kenya. Information from this activity will guide the development of information, education

and communication material targeting policy makers, health care workers and the community with the aim

of changing misconceptions about injections and promoting rational injection use and safe injection

practices.

3. CONTRIBUTIONS TO OVERALL PROGRAM AREA Strategic information from this activity will guide

intervention programs in Injection Safety as well as all HIV/AIDS prevention and treatment and infection

prevention and control interventions in the Ministry of Health. Additionally, the strategic information will form

a basis for monitoring and evaluating the success of injection safety interventions. As the HIV treatment

program is scaled up and brings more HIV/AIDS patients to health care facilities, measures must be put in

to place to protect health care workers and other patients from nosocomial infections. This program will

contribute to the aversion of up to 5% new cases of HIV in the country.

4. LINKS TO OTHER ACTIVITIES

This activity is linked to injection safety initiatives implemented by the Ministry of Health, National AIDS and

STI Control Program (NASCOP) (#7010), Danya International (#8824) and JHPIEGO (#8821) and to

PEPFAR care and treatment programs.

5. POPULATIONS BEING TARGETED

This activity targets all health care workers, nurses, doctors, clinical officers, lab personnel, health care

waste handlers, policy makers and the general public.

6. EMPHASIS AREAS

This activity consists of two targeted evaluations and minor emphasis in advocacy, development and

dissemination of policies, guidelines and protocols for best practice and evidence-based approaches. This

activity will also contribute to local organization capacity development.

New/Continuing Activity: New Activity

Continuing Activity:

Emphasis Areas

Health-related Wraparound Programs

* Safe Motherhood

Human Capacity Development

Public Health Evaluation

Food and Nutrition: Policy, Tools, and Service Delivery

Food and Nutrition: Commodities

Economic Strengthening

Education

Water

Table 3.3.05:

Funding for Treatment: Pediatric Treatment (PDTX): $100,000

ACTIVITY UNCHANGED FROM COP 2008:

1. LIST OF RELATED ACTIVITIES

This activity relates to activities in ARV Services.

2. ACTIVITY DESCRIPTION

It is estimated that there are 100,000-150,000 HIV-infected children in Kenya of which ~40,000 will require

antiretroviral treatment (ART). As scale-up of ART services has increased substantially among adults,

pediatric ART services have lagged behind. As of March 2008, only 240 (60%) of 400 ART sites were

providing pediatric services to ~18,000 children. Strategies to improve pediatric ART enrollment include

pediatric counseling, pediatric ART training and mentorship, caregiver programs, expansion of the early

infant diagnosis, and pediatric testing campaigns. Surveillance of pediatric care in Kenya will measure

process and outcomes of enrollment into care by pediatric patients. It will look at both community and

facility referral systems, and include measures of clinical/laboratory staging, retention, ART initiation and

maintenance, morbidity and mortality. The University of Nairobi Obstetrics and Gynecology (UNOG)

Department has been identified as the prime partner for this activity. The Protocol is being developed by

UNOG in collaboration with other implementing partners, CDC, other USG agencies, and National AIDS

and STD Control Program and should be completed in FY08. The completion of data collection using COP

08 funding is anticipated. Additional funding is requested in FY09 COP for data analysis and report writing.

3. CONTRIBUTIONS TO OVERALL PROGRAM AREA

These activities will contribute to the programmatic evaluation of the national Pediatric care and ART.

results of these evaluation will be used to improve pediatric care and treatment enrollment

4. LINKS TO OTHER ACTIVITIES

This activity relates to national pediatric care and support, pediatric ARV services and PMTCT services

supported by the National AIDS and STD Control program (NASCOP) and PMTCT services supported by

this partner.

5. POPULATIONS BEING TARGETED

These activities target, children and, infants.

6. KEY LEGISLATIVE ISSUES ADDRESSED

This activity addresses legislative issues related to stigma and discrimination through community

sensitization activities.

7. EMPHASIS AREAS

This activity will collect strategic information about pediatric patients.

New/Continuing Activity: Continuing Activity

Continuing Activity: 17156

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

17156 17156.08 HHS/Centers for University of 7017 303.08 Department of $100,000

Disease Control & Nairobi Obstetrics and

Prevention Gynecology

Table 3.3.11:

Cross Cutting Budget Categories and Known Amounts Total: $81,000
Human Resources for Health $81,000
Public Health Evaluation $0