Detailed Mechanism Funding and Narrative

Years of mechanism: 2010 2011 2012 2013 2014

Details for Mechanism ID: 11708
Country/Region: Botswana
Year: 2012
Main Partner: U.S. Centers for Disease Control and Prevention
Main Partner Program: NA
Organizational Type: Implementing Agency
Funding Agency: HHS/CDC
Total Funding: $450,000

There are differences in TB and HIV prevalence and population dynamics between the Western and Southern areas of Botswana which offer a unique opportunity for the study and comparison of the transmission dynamics of TB and MDR TB in stable/aggregated and dynamic/open populations and determine the effect of HIV on these transmission dynamics. Molecular epidemiology provides unique opportunities to understand crucial aspects of the transmission dynamics of TB in the community that could lead to successful public health interventions.

This Molecular Epidemiology Program will be a collaborative project between the Government of Botswana, the Botswana-University of Pennsylvania Partnership and CDC. We will combine classical epidemiologic methods and molecular epidemiology to determine the transmission dynamics of TB in closed/clustered (Western region) and open/dynamic (Southern region) populations in Botswana and the effect of HIV infection and drug-resistance on TB transmission in these settings. Mathematical models of TB epidemics using real-world data generated will be developed to measure the effectiveness of different public health interventions to interfere with TB transmission and to guide the Ministry of Health to direct infection control measures towards hotspots of TB transmission in the country.

Funding for Care: TB/HIV (HVTB): $450,000

Of the $450,000 set aside for the TB/HIV Program, $200,000 will be for cost share operational expenses. An additional $250,000 will be used to procure and set up a containerized BioSafety Level (BSL) 3 lab in Ghanzi. This lab will be used to conduct DNA fingerprinting of TB isolates from the Ghanzi area which has the highest TB rates in the country. The data will be used by the National Tuberculosis Program to direct infection control measures towards hotspots of TB transmission in the country. The Molecular Epidemiology Program is a collaborative project with the Government of Botswana, the University of Pennsylvania, and CDC and is funded by CDC and NIH.

Cross Cutting Budget Categories and Known Amounts Total: $250,000
enumerations.Construction/Renovation $250,000
Key Issues Identified in Mechanism