Detailed Mechanism Funding and Narrative

Details for Mechanism ID: 11094
Country/Region: Botswana
Year: 2009
Main Partner: U.S. Centers for Disease Control and Prevention
Main Partner Program: NA
Organizational Type: Own Agency
Funding Agency: HHS/CDC
Total Funding: $326,269

Funding for Sexual Prevention: Other Sexual Prevention (HVOP): $50,000

09.P.OP18: CDC HPR - Truvada Study

HIV pre-exposure prophylaxis (PrEP) is commonly defined as the oral use of antiretroviral agents (ART) to

prevent HIV transmission. In part based on the success of ART for prevention of HIV mother-to-child

transmission and after post-occupational HIV exposure, PrEP is still considered to be one of the more

promising HIV prevention tools being explored with seven current or planned clinical trials worldwide

evaluating this approach. If effective this approach may be able to prevent up to 3 million people in sub-

Saharan Africa from getting HIV over the next 10 years.

The Centers for Disease Control and Prevention are currently conducting a phase 3 safety and

effectiveness trial of the two drug combination of tenofovir and emtricitabine (TDF/FTC) among

heterosexual men and women in two cities in Botswana. Given the potential benefit of this approach, the

Government of Botswana is very eager to initiate discussions regarding possible implementation. Any

discussions regarding implementation, however, will require substantial input over several meetings from

the multitude of stakeholders both locally and well as internationally, e.g., WHO, UNAIDS. We request

funding support to assist with these programmatic discussions. With this funding we will be able to arrange

for meeting venues, printing services, and other meeting services. Since at least two studies will be

conducting interim efficacy analyses in 2009, policy makers will need to decide soon whether PrEP is worth

their investment.

New/Continuing Activity: New Activity

Continuing Activity:

Table 3.3.03:

Funding for Care: TB/HIV (HVTB): $140,000

09.C.TB08: HHS/CDC/BOTUSA TB Section Support


From COP08:

This activity will provide care, preventive therapy and appropriate service referrals for 2,000 adult PLWHA

as part of an ongoing HHS/CDC/BOTUSA project. These individuals will be seen on at least a monthly

basis and they will receive regular checkups by registered nurses. Each will be provided 6 months of IPT;

eligible patients will be linked to services providing ARV treatment and CPT. Patients will be regularly

screened for adverse effects of medications and symptoms of opportunistic infections. Referrals to HIV

support groups, alcohol dependence counseling, psychiatric support, and PMTCT services will be made as

appropriate. Health education will be provided to all patients about living with HIV-infection, and about HIV

services available to them.

Referrals for ARV treatment and CPT will be provided to approximately 1,000 PLWHA. Quality care

through at least monthly check ups will be provided to reduce morbidity and mortality. Data from these

services will also be used to inform the ongoing National Comprehensive HIV Program.

New/Continuing Activity: Continuing Activity

Continuing Activity: 17347

Continued Associated Activity Information

Activity Activity ID USG Agency Prime Partner Mechanism Mechanism ID Mechanism Planned Funds

System ID System ID

17347 10170.08 HHS/Centers for US Centers for 7732 5406.08 Local Base $140,000

Disease Control & Disease Control

Prevention and Prevention

10170 10170.07 HHS/Centers for US Centers for 5406 5406.07 Local Base $350,000

Disease Control & Disease Control

Prevention and Prevention

Table 3.3.12:

Funding for Management and Operations (HVMS): $136,269

09.X.MS93: HHS/CDC Management and Support

This is a continuing activity from FY2008 and is supported with both GAP and GHCS (State) funds.

Funds requested between GHCS (State) and GAP accounts will support staff salaries/allowances and

related office support, including travel, communications, equipment, and miscellaneous procurement, etc.

Including all program area technical staff, PEPFAR supports 55 FTE positions. No new positions are being

requested for FY2009. Most of the operations staff is shared across three CDC Divisions working in

Botswana. An additional 22 individuals representing almost 7.0 full time equivalents provide some portion of

their time to support PEPFAR activities and are funded by either the Divisions of HIV/AIDS Prevention or

Tuberculosis Elimination. The following positions are currently supported with Management and Staffing


Country Director, USDH

Associate Director-Management and Operations, USDH

Associate Director, GAP, USDH

GAP Senior Administrator, USDH

Associate Director for Science, USDH

Communications Officer, contractor

Building and Design Coordinator, contractor

Program Specialist, contractor

Financial Chief, LES

Secretary, LES (3)

Receptionist, LES (2)

Administrative Assistant, LES (3)

Janitress/laborer (6)

Drivers, LES (3)

Program Assistant

New/Continuing Activity: New Activity

Continuing Activity:

Table 3.3.19: